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Quiet & Productive Biological Sample Concentrator
27 Nov 2008: The versatile, budget priced miVac Duo biological sample concentrator from Genevac rapidly removes a wide range of solvents. Featuring a high displacement pump, the unit typically removes water up to 40% faster than similar concentrators and is extremely quiet. The compact size of the miVac Duo saves valuable bench space, and its simple, robust design provides years of reliable service even when used intensively. Genevac
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Determination of Polyolefin branching structure and molecular weight by High Temperature Gel Permeation Chromatography (GPC/SEC)
27 Nov 2008: Viscotek, a Malvern Instruments group company, has announced a new technical article that describes and illustrates how High Temperature GPC/SEC offers scientists a breakthrough technique for determining the molecular weight and branching structure of polyolefins. Viscotek Europe
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3M Empore™ SPE and Filter Plates
23 Oct 2008: Empore™96-Well Plates provide a means of high throughput sample preparation by processing 96 samples in a standard 8x12 microcolumn plate format compatible with standard 96-well plate liquid handling technologies and injection systems. Empore™ 96-Well Plates are available for solid phase extraction (SPE) and for filtration after protein precipitation. 3M Bioanalytical
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860 KF Thermoprep - simple, safe and precise sample preparation
21 Oct 2008: The 860 KF Thermoprep is the new Metrohm instrument for thermal sample preparation in Karl Fischer titration. It can be combined with a wide range of titrators for volumetric and coulometric water determination. Metrohm AG
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Automated dialysis as a sample preparation tool in ion chromatography 10 Sep 2008: Running difficult samples with Metrohm's automated compact stopped-flow dialysis provides optimum separation and protects your column from detrimental compounds. Using as examples an ultra-high temperature (UHT) processed milk and a baby milk powder sample, this application note presents a fully automated sample preparation setup coupled to the new ion chromatograph 881 Compact IC pro. Metrohm AG
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Fully automated sample preparation for the content determination of tablets 10 Sep 2008: The content of benzbromaron in tablets can be effectively determined by titration with sodium hydroxide solution using a straightforward, fully automated sample preparation. The results in this application note show an excellent agreement with the benzbromaron amount indicated by the manufacturer. Metrohm AG
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Automated Sample Preparation for Tablet Analysis: Metrohm's 815 Robotic Soliprep
02 Sep 2008: Before ingredients in pharmaceutical tablets can be determined, sample preparation steps have to be performed that require substantial effort. Automation with Metrohm's 815 Robotic Soliprep speeds up sample preparation while improving reproducibility and accuracy. Metrohm AG
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Recommended Procedures for HybridSPE™ - Precipitation (HybridSPE-PPT) 96-well Plates & Cartridges 01 Sep 2008: It is well known that phospholipid contamination is one of the principal causes of ion-suppression when analyzing small molecules in biological matrixes via LC-MS-MS. HybridSPE - Precipitation technology is a simple and generic sample prep platform designed for the gross level removal of endogenous protein and phospholipid interferences from biological plasma and serum prior to analysis. Two methods are available: an "In-Well Precipitation" method and an "Off-line Precipitation" method. Sigma-Aldrich Corporation
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Introducing HybridSPE™ Precipitation Technology for Pharmaceutical Bioanalytical Sample Preparation 01 Sep 2008: Advances in LC-MS technology have reaped throughput and sensitivity benefits in pharmaceutical bioanalysis, good sample preparation continues to be a critical component of bioanalysis. This report explains a new sample prep platform combining two predominate techniques in bioanalytical sample prep: protein precipitation and SPE. The end result is a technique that offers the advantages of both approaches while minimizing their disadvantages. Sigma-Aldrich Corporation
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Comparative Extraction and LC-MS-MS of 10 ng/mL Clenbuterol (R(-) and S(+) enantiomers) in Rat Plasma 01 Sep 2008: In this application example, rat plasma samples were spiked with clenbuterol (R(-) and S(+) enantiomers) at the level of 10 ng/mL and extracted using three different procedures: Hybrid- SPE-PPT, Protein PPT, and a 9-step SPE procedure optimized for trace level clenbuterol analysis. Comparisons of sample preparation methods were made in terms of the amount of phospholipids in the sample extract and the overall effect on signal response of clenbuterol enantiomers. Sigma-Aldrich Corporation
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